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RDC 752/2022 — GMP (CBPF)

RDC 752/2022 establishes the Good Manufacturing Practices (GMP) requirements for medical device manufacturers and importers in Brazil — forming the basis for the CBPF (Certificado de Boas Práticas de Fabricação).

RDC 752/2022 is closely aligned with ISO 13485:2016 and covers:

  • Quality management system requirements;
  • Management responsibility;
  • Resource management;
  • Product realisation (design, purchasing, production, service);
  • Measurement, analysis and improvement (internal audit, CAPA, complaints); and
  • Documentation and record keeping.

For foreign manufacturers, an ISO 13485:2016 certificate from an accredited certification body (INMETRO-recognised or equivalent) is generally accepted as equivalent evidence of GMP compliance under RDC 752/2022 for registration purposes.


Official sources

Verify all information against official ANVISA sources before making regulatory decisions.